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Endep Antidepressant : Amitriptyline

Brand Name : Amitriptyline

Amitriptyline is an antidepressant medication. Depression is an all-pervasive sense of sadness and gloom. In some patients with depression, abnormal levels of brain chemicals called neurotransmitters may relate to their depression. Amitriptyline elevates mood by raising the level of neurotransmitters in brain tissue.

Uses of Endep

  • Amitriptyline is used to elevate the mood of patients with depression.
  • Amitriptyline is also a sedative, and is useful in depressed patients with insomnia, restlessness, and nervousness. It has also been found to be helpful for treating fibromyalgia and symptoms related to chronic pain.
  • Amitriptyline (Elavil) is a tricyclic antidepressant used to treat depression.
  • It may also be used to treat chronic pain and other conditions as determined by your doctor.
  • Amitriptyline is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide. Amitriptyline is also sometimes used to treat certain types of pain.
  • Amitriptyline may also be used for purposes other than those listed in this medication guide.

How to Take Endep

  • Amitriptyline may be taken with or without food. Amitriptyline is metabolized by the liver and should be used with caution in patients with liver dysfunction.
  • Take amitriptyline exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
  • Take each dose with a full glass (8 oz) of water.
  • Amitriptyline may be taken several times a day or in one daily dose (usually at bedtime). Follow your doctor's instructions.
  • Do not stop taking amitriptyline suddenly. This could cause symptoms such as nausea, headache, and malaise.

What are the Side Effects of Endep Medication

If you experience any of the following serious side effects, stop taking amitriptyline and contact your doctor immediately or seek emergency medical treatment:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, face, or tongue; or hives)
  • seizures
  • a fast or irregular heartbeat
  • a heart attack
  • difficulty urinating
  • fever with increased sweating
  • muscle stiffness
  • severe muscle weakness

Warnings and precautions before taking Endep Medication

  • Before taking amitriptyline, tell your doctor or pharmacist if you are allergic to it, or to other tricyclic antidepressants (e.g., nortriptyline), or if you have any other allergies.
  • This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a certain eye problem (untreated narrow-angle glaucoma), a heart attack in the last 30 days.
  • Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, kidney problems, liver problems, heart problems, problems urinating (e.g., due to enlarged prostate), eating disorders (e.g., bulimia), overactive thyroid (hyperthyroidism), long-term lung problems (e.g., pulmonary insufficiency), a certain eye problem (open-angle glaucoma), personal or family history of mental/mood conditions (e.g., bipolar disorder, psychosis), family history of suicide, seizures, conditions that may increase your risk of seizures (e.g., other brain disease, alcohol withdrawal).
  • This drug may make you drowsy or dizzy or cause blurred vision; use caution engaging in activities requiring alertness or clear vision such as driving or using machinery. Limit alcoholic beverages.
  • To minimize dizziness and the risk of fainting, get up slowly when rising from a sitting or lying position.
  • Before having surgery, tell your doctor or dentist that you are taking this medication.

What drugs may interact with Endep Tablet

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious (possibly fatal) interactions may occur: arbutamine, sibutramine, disopyramide, iomeprol, cisapride, pimozide, halofantrine, lumefantrine, MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine).

Avoid taking MAO inhibitors within 2 weeks before and after treatment with this medication. In some cases a serious, possibly fatal drug interaction may occur.

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting amitriptyline.

What to do if you take Overdose of Endep ?

Seek emergency medical attention. Symptoms of an amitriptyline overdose include:

  • seizures
  • confusion
  • drowsiness
  • agitation
  • hallucinations
  • low blood pressure (dizziness, fatigue, fainting).

How to Store Endep ?

Amitriptyline should be stored at room temperature in a tight, light resistant container. Store amitriptyline at room temperature away from moisture and heat. Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.


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Disclaimer: is designed to help and support for people who have depression or are depressed. It is not intended to treat, diagnose, cure, or prevent any psychiatric, psychological or mental diseases. Always take the advice of professional health care for specific medical advice, diagnoses, and treatment. We will not be liable for any complications, or other medical accidents arising from the use of any information on this web site.