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Desipramine Antidepressant : Norpramin

Brand Name : Norpramin

Desipramine is a tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine. It is sold under the brand names Norpramin® and Pertofrane®. It is used to treat depression, but not considered a first line treatment since the introduction of SSRI antidepressants. Desipramine is an active metabolite of imipramine.

Uses of Desipramine

  • Desipramine is a medication that is used to treat depression, defined as an all-pervasive sense of sadness and gloom. Desipramine belongs to the tricyclic class of antidepressants called tricyclic antidepressants or TCAs. In some patients with depression, abnormal levels of neurotransmitters in the brain (chemicals that the nerves use to communicate with each other) may be responsible for the depression.
  • This medicine is used for the treatment of depression, anxiety disorders, obsessive and compulsive symptoms, panic disorder, eating disorders, chronic and pain conditions.
  • It is also used to prevent migraine headaches and bedwetting in children.

How to Take Desipramine

  • Norpramin should be taken exactly as prescribed.
  • Do not stop taking Norpramin if you feel no immediate effect. It can take up to 2 or 3 weeks for improvement to begin.

What are the Side Effects of Desipramine Medication

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Norpramin. Side effects may include:

  • Abdominal cramps
  • agitation
  • anxiety
  • black tongue
  • black
  • red or blue spots on skin
  • blurred vision
  • breast development in males
  • breast enlargement in females
  • confusion
  • constipation
  • delusions
  • diarrhea
  • dilated pupils
  • disorientation
  • dizziness
  • drowsiness
  • dry mouth
  • excessive or spontaneous flow of milk
  • fatigue
  • fever
  • flushing
  • frequent urination or difficulty or delay in urinating
  • hallucinations
  • headache
  • heart attack
  • heartbeat irregularities

Warnings and precautions before taking Desipramine Medication

  • Before using Norpramin, tell your doctor if you have heart or thyroid disease, a seizure disorder, a history of being unable to urinate, or glaucoma.
  • Nausea, headache, and uneasiness can result if you suddenly stop taking Norpramin. Consult your doctor and follow instructions closely when discontinuing Norpramin.
  • This drug may impair your ability to drive a car or operate potentially dangerous machinery. Do not participate in any activities that require full alertness if you are unsure about your ability.
  • Norpramin may increase your skin's sensitivity to sunlight. Overexposure could cause rash, itching, redness, or sunburn. Avoid direct sunlight or wear protective clothing.
  • If you are planning to have elective surgery, make sure that your doctor is aware that you are taking Norpramin. It should be discontinued as soon as possible prior to urgery.
  • Tell your doctor if you develop a fever and sore throat while you are taking Norpramin. He may want to do some blood tests.

What drugs may interact with Desipramine Tablet

People who take antidepressant drugs known as MAO inhibitors (including Nardil and Parnate) should not take Norpramin.

If Norpramin is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Norpramin with the following:

  • Cimetidine (Tagamet)
  • Drugs that improve breathing, such as Proventil
  • Drugs that relax certain muscles, such as Bentyl
  • Fluoxetine (Prozac)
  • Guanethidine (Ismelin)
  • Paroxetine (Paxil)
  • Sedatives/hypnotics (Halcion, Valium)
  • Sertraline (Zoloft)
  • Thyroid medications (Synthroid)

What to do if you take Overdose of Desipramine ?

Any medication taken in excess can have serious consequences. An overdosage of Norpramin can be fatal. If you suspect an overdose, seek medical help immediately. Symptoms of overdose may include:

  • Agitation
  • coma
  • confusion
  • convulsions
  • dilated pupils
  • disturbed concentration
  • drowsiness
  • extremely low blood pressure
  • hallucinations
  • high fever
  • irregular heart rate
  • low body temperature
  • overactive reflexes
  • rigid muscles
  • stupor
  • vomiting

How to Store Desipramine ?

Desipramine should be stored below 86° F (30°C) in a tight, light resistant container.


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Disclaimer: is designed to help and support for people who have depression or are depressed. It is not intended to treat, diagnose, cure, or prevent any psychiatric, psychological or mental diseases. Always take the advice of professional health care for specific medical advice, diagnoses, and treatment. We will not be liable for any complications, or other medical accidents arising from the use of any information on this web site.